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KMID : 1149120190160010008
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Journal of the Korean Society for Psoriasis
2019 Volume.16 No. 1 p.8 ~ p.13
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Skin and Intestinal Microbiome in Psoriasis
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Jeong Ki-Heon
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Abstract
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The human body is colonized by millions of microbiome. Continuous cross-talk between microbiome and immune system plays an essential role in host homeostasis. Dysbiosis (change in microbial diversity and community composition) is associated with many chronic inflammatory diseases, including psoriasis. Psoriasis is an immune-mediated chronic inflammatory disease. Although its pathogenesis is not fully understood, it is hypothesized to be multi-factorial, influenced by genetic and environmental factors. Recently, skin and intestinal microbiota have been gaining attention for the pathogenesis of psoriasis. However, microbiome studies remain controversial due to conflicting study results. The skin microbiota plays a crucial role in maintaining integrity and function in critically exposed barrier. Modification of the composition of skin microbiota could affect the local T cell subsets and local inflammation but does not seem to affect distant sites. The gut microbiota provides essential health benefits to the host, particularly by maintaining intestinal mucosal barrier and normal immune function. Interestingly, the intestinal microbiota is able to affect systemic immune system and distant sites, such as skin, joint, liver, nervous and cardiovascular systems. The microbial imbalance in gut could affect development of Th17 cells, increase of gut permeability, bacterial translocation, and inflammation. Further studies of functional, metabolic, and immunological impact of microbial communities in psoriasis are needed.
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KEYWORD
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Intestine, Microbiome, Microbiota, Psoriasis, Skin
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